Pediatric Renal Transplantation

Transplantation is the preferred method of treatment for end-stage renal disease in children. The rate ofpediatric kidney transplantation has been steadily rising over the past decade. The use of increasingly potent immunosuppressive drugs has lessened the risk for acute rejection substantially and improved short-term outcomes; however, the long-term outcomes have remained inadequate
Renal transplantation is the treatment of choice for pediatric patients with end-stage renal failure. Living donor transplantation (LDT) has become an important therapeutic option due to the shortage of cadaver donors and increasingly long waiting times. In a living-donor transplant, an adult (18 or older) gives one kidney to the child. The donor can be either a family member or someone unrelated, such as an adult family friend. The potential donor will first undergo a series of tests to measure compatibility.
Kidney transplantation involves more than simply an operation. Human leukocyte antigens (HLA) and panel reactive antibody (PRA)

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